ANTIDIABETIC EFFECT OF CINNAMON (CINNAMONUM ZEYLANICUM) USED TO CONTROL DIABETES MELLITUS IN ALLOXAN INDUCED DIABETIC MALE RABBITS

Abstract

This study was carried out to check the effect of Cinnamon (Cinnamonum zeylanicum) aqueous extract oral administration on serum glucose, cholesterol, and urea level and body weight in normal and Alloxan-induced diabetes male rabbits. Alloxan monohydrate (120mg/kg) was used to induce diabetes mellitus in twelve hours fasted male rabbits. After seven days of alloxan monohydrate induction diabetes mellitus was confirmed animals with fasting serum glucose level more than 250mg/dl and were considered as diabetes. 50% mortality rate was noted. In 1st step of experimental work, twenty one male rabbits were divided in to seven experimental groups each group contains three male rabbits, 1st group normal and 2nd group diabetic control and 3rd to 7th group containing male rabbits were treated with 0.50%, 0.75%, 01%, 1.25%, 1.50% Cinnamon aqueous extract to check the effective dose against diabetes. In 2nd step of experimental work nine male rabbits were selected and each group contains three male rabbits 1st and 2nd group contains normal and diabetic controls and 3rd group is treated with most effective dose of Cinnamon to check its effect against serum glucose level and together with serum cholesterol level, serum urea level and body weight. Whole experiment was designed for the period of two months. Blood serum was used to determine all selected biochemical parameters, on every third day. It was observed that in 1st step 1% Cinnamon treated male rabbits showed significant hypoglycemic effect which decreased 52.38% serum glucose level where as in 2nd step of experimental work 1% Cinnamon controlled 54.11% serum glucose level, 35.25% serum cholesterol level and 34.55% serum urea level and body weight was gradually decreased. It is concluded that oral administration of Cinnamon aqueous extract decreases serum glucose, cholesterol and urea level in diabetes induced male rabbits