A REVIEW ON BIOTRANSFORMATIONAL STUDIES OF DANAZOL

Abstract

Biotransformation is the basis of life. Various chemical modifications are occurred by drugs in the body to give metabolites as new molecules having their own features, generally different from those of drug. Danazol (1) is used more effectively for the treatment of endometriosis and benign fibrocystic mastitis. As a result of biotransformation of danazol (1) variety of metabolites, 2-17 were identified by using different sources including a monkey, human (male and female) volunteers and horse, and fermentation with Cephalosporium aphidicola, Aspergillus niger, Fusarium lini, Fusarium solani, Gibberella fujikuorii and Bacillus cerus. This present review will discuss metabolites 2-17, obtained from danazol (1) up to 2012.