AN UPDATE ON BIOTRANSFORMATIONAL STUDIES OF DYDROGESTERONE
Keywords:
Azadirachta indica, Biotransformation, Cephalosporium aphidicola, Cunninghamella elegans, Dydrogesterone, Fusarium lini, Fusarium solani, Gibberella fujikuroi, Rhizopus stolonifer, Sepedeonium ampullosAbstract
Due to the result of enzymatic or metabolic activities by a living organism, the series of chemical reactions occur in a compound, especially a drug. Dydrogesterone (1) is a potent orally active progestogen. Biotransformation of dydrogesterone (1) by using human volunteers, rat, dog, mouse, rabbit and rhesus monkey, by fermentation with cell suspension cultures of Sepedeonium ampullos and Azadirachta indica, and fermentation with fungal cultures including Fusarium solani, Cephalosporium aphidicola, Fusarium lini, Rhizopus stolonifer, Cunninghamella elegans and Gibberella fujikuroi afforded metabolites 2-16. This review article will provide detail about metabolites 2-16, obtained by biotransformation of dydrogesterone (1) and have been reported up to 2012
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