ESTIMATION OF MINIMUM INHIBITORY CONCENTRATION OF ANTIBIOTICS USING MICRO-TITER PLATE METHOD FOR NATIVE MULTI DRUG RESISTANT GRAM NEGATIVE BACTERIA
DOI:
https://doi.org/10.34016/pjbt.2023.20.01.773Keywords:
gram-negative, resistant, MDR, clinical, antibioticsAbstract
Gram-negative bacteria were collected from different clinical labs situated in Karachi. Of these 83 isolates, 99% were found resistant against one or more of the following antibiotics: ampicillin, co-amoxiclav, gentamycin, neomycin, streptomycin and tetracycline. Most of the isolates were multi-drug resistant (MDR) having resistance to three or more antibiotics at a time. For ampicillin, 4.8% of the isolates were found Susceptible, 3.6% were Intermediate while 91.5% were found Resistant. For co-amoxiclav, 1.2% of the isolates were found Susceptible, 6% were Intermediate while 92.7% were found Resistant. For gentamicin, 3.6% of the isolates were found Susceptible, 10.8% were Intermediate while 86.7% were found Resistant. For neomycin, 21.6% of the isolates were found Susceptible, 40.9% were Intermediate while 43.4% were found Resistant. For streptomycin, 1.2% of the isolates were found Susceptible, 18% were Intermediate while 91.6% were found Resistant. For tetracycline, 15.7% of the isolates were found Susceptible, 45.7% were Intermediate while 53% were found Resistant. The study confirmed the presence of multidrug resistance in indigenous clinical gram-negative bacteria which is an alarming situation and needs development of effective alternative strategies for the treatment of infections.
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Copyright (c) 2023 Kanwal Ibrahim, Asma Saeed, Sadia Khalil, Amna Alam
This work is licensed under a Creative Commons Attribution 4.0 International License.