ETIOLOGICAL EVALUATION OF PANCYTOPENIA IN CHILDREN AND ADULT PATIENTS BASED ON BONE MARROW BIOPSY

Abstract

To assess the etiological background of pancytopenia based on bone marrow biopsies in children and adult patients was
conducted at tertiary care hospitals of Hyderabad Pakistan. It is a retrospective study in which 134 pancytopenic patients from
both pediatric and adult groups were included. Clinical background and microscopic findings of bone marrow biopsies were
examined. In children age group, it was assessed that acute lymphoid leukemia was most striking cause (25%), followed by
infection related changes (21.66%), reactive bone marrow (11.66%), and megaloblastic anemia (10%).While in adult age group
the most widespread cause of pancytopenia was megaloblastic anemia (24.32%), followed by infection related changes
(17.56%), hypocellular bone marrow (8.1%) and others. Urgent evaluation of pancytopenic patients is very necessary at earlier
stage before it turns in to diverse and dangerous etiological changes.Pancytopenia, adult, children, bone marrow, etiology.