EFFECT OF INJECTION OF HUMAN MENOPAUSAL GONADOTROPHIN AND HUMAN CHORIONIC GONADOTROPHIN HORMONE ON SPERMATOGENESIS OF ADULT MALE MICE

Abstract

This study was designed to investigate the effect of the widely-used gonadotrophin hormones (Human Menopausal Gonadotrophin and Human Chorionic Gonadotrophin) on spermatogenesis of adult male albino mice. Thirteen mature swiss mice of Balb/C strain were used in this study. They were divided randomly into control and treated groups. Male mice in the first and second treated groups had been injected intramuscularly with (75 IU of hMG) and (500 IU of hCG) Every 48 hr, for 35 days of this dose. While the mice of the control groups had been injected with (0.9%) normal saline in the same way. The results revealed the following significant differences , when compared with control groups : There were no significant differences in weights of the reproductive organs and there were no significant differences in average of the percentage of spermatogonia and spermatocytes, While the study reports a significant decrease (P<0.05) in the percentage of spermatids of animals treated with hMG hormone and a significant increase (P<0.01) in the percentage of spermatozoa of animals treated with hMG hormone and also A significant decrease (P<0.01) in the average numbers of Leydig cells for the animals treated with hMG and hCG hormones and A significant decrease (P<0.01) in the average diameters of epididymal tubules and the height of epithelial cells of caput epididymis tubules for two animals with hMG and hCG .