COMPARATIVE ANTIHYPERGLYCEMIC ACTIVITY OF AQUEOUS EXTRACTS OF GARLIC (ALLIUM SATIVUM) AND GINGER (ZINGIBER OFFICINALE) IN ALLOXAN-INDUCED MALE RABBITS

Abstract

This study was undertaken to investigate the effect of Garlic (Allium sativum) and Ginger
(Zingiber officinale) aqueous extracts on serum glucose, cholesterol, urea levels and body weight in
normal and alloxan-induced diabetic male rabbits. Before alloxan monohydrate (120mg/kg)
introduction rabbits were left in fasting condition till twelve hours. After seven days of alloxan
monohydrate induction diabetes mellitus was confirmed animals with fasting serum glucose level ≥
250mg/dl and were considered as diabetes. In whole experimental work twelve male rabbits were
selected divided in to four groups and each group contains three male rabbits 1st and 2nd group
normal and diabetic control 3rd to 4th group containing male rabbits were treated with 1% garlic and
ginger aqueous extract to check the comparison between them against serum glucose and their
variable effects on serum cholesterol, serum urea and body weight. Blood serum was used to
determine all selected biochemical parameters, on every third day. It was observed that 1% Garlic
and ginger aqueous extract controlled 51% and 45.26% glucose, 35.29% and 21.95% cholesterol,
46.22% and 21.69% urea level and body weight gradually increased in alloxan induced diabetic
male rabbits. It is observed in the present investigation that oral administration of garlic and ginger
aqueous extracts are hypoglycemic agents but according to the results garlic is the best
hypoglycemic agent, which also controlled cholesterol and urea level more than ginger in alloxaninduced
diabetic male rabbits