SOME HEPATIC AND RENAL HISTOLOGICAL AND PHYSIOLOGICAL EFFECTS OF THE ARTIFICIAL TESTOSTERONE (SUSTANON) ON FEMALE RATS

Abstract

This experimental study was carried out to investigate the effects of three different doses of artificial testosterone (sustanon) on the histological structure and the function of liver and kidney. For this experiment 48 adult female rats divided into four groups received 0.05, 0.1, 0.2 mg/kg respectively in addition to one control group for a period of 42 days. Blood samples were collected at the end of the experiment for liver enzymes levels analysis. Then the animals were sacrificed and dissected out to remove liver and kidneys for histopathological study. The results showed significant changes in liver enzymes compared with control group. All treated groups showed enlargement and congestion in hepatocytes and nephrons. In addition to that, Cellular swelling, vacuolar degeneration, fatty changes and apoptosis were noticed in all treatment groups. It was concluded from this study that artificial testosterone at the above doses had hepatic and renal histological and physiological changes in female rats and these findings suggesting a similar effect in human.