SERUM TUMOR NECROSIS FACTOR Α AND INTERLEUKIN-10 ASSAY IN NASSIRYHIAN IRAQI PATIENTS WITH HYPOTHYROIDISM

Abstract

Tumor Necrosis Factor α and Interleukin-10 are inflammatory cytokines has a significant role in the pathogenesis of immunological inflammatory processes at multiple levels.
The study was performed on 80 Iraqi patients attended Endocrine and diabetic Medical center in Nassiryhia, with hypothyroidism and 23 healthy adults were enrolled. All subjects were (20-53) years old.
Thyroid hormones triiodothyronine (T3) and thyroxin (T4), concentrations were (1.62 ± 0.399) vs (1.98 ± 1.119) nmol/l, (104.55 ± 48.27) vs (92.03 ± 13.71) nmol/l not significant increase in patients than in control respectively, while thyroid stimulating hormone (TSH) concentrations were (17.63 ± 29.16) vs (2.138 ± 1.09) μIu/lP (0.013*) significant increase in patients than in control.
This study supports the fact that some cytokines may play a role in hypothyroidism, so there are a Significant increase of TNF-α and IL-10 concentration in patients when compared with the healthy controls (p<0.001 for both) (Mean ± standard deviation) (277.5±253.1), and (214 ±168.3) pg/ml and (7.34±3.3) and (4.75±0.62) respectively.
This finding may indicate that hypothyroidism might influence cytokine production in these patients.