MOLECULAR APPROACH FOR EARLY DIAGNOSIS OF HEPATOCELLULAR CARCINOMA IN EGYPTIAN PATIENTS BY ALPHA FETOPROTEIN (AFP) AND VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF)

Abstract

The primary marker for Hepatocellular Carcinoma (HCC) is AFP. Generally AFP shows
acceptable sensitivity, however AFP is not secreted in all cases of HCC and may be normal as
many as 40 % of patients with early HCC .This work aims to study and to evaluate biochemical
diagnosis of HCC by comparing liver functions including Alpha fetoprotein (AFP) and its rule
as a tumor marker or HCC in different groups that studied (Cases of HCC, cases at high risk,
chronic hepatitis and cirrhosis against control group) and evaluated the value of measuring
serum Alpha fetoprotein(AFP) and Vascular Endothelial Growth Factor (VEGF) for early
diagnosis of HCC in HCC cases and in high risk groups. This study was conducted on three
groups, group І cases of (HCC) (35 patients),group Π cases at high risk to develop HCC
(Cirrhosis, HBs Ag positivity and Anti-HCV) (35 patients), selected from the National Liver
Institute, Menoufiya University and Group Ш 30 healthy control persons.