In-Silico ANALYSIS OF THE GENE AND PROTEIN SEQUENCES OF THE ENZYME MUSHROOM TYROSINASE (POLYPHENOL OXIDASE, PPO)

Authors

  • Mahmud Tareq Hassan Khan
  • Atta-ur Rahman
  • M. Iqbal Choudhary

Keywords:

Tyrosinase, Polyphenol oxidase, copper, melanin, hyperpigmentation, depigmentation, melanoma, TRP1, TRP2, bioinformatics.

Abstract

Tyrosinase (E.C. 1.14.18.1) is a multifunctional copper-containing enzyme which catalyses the biosynthesis of melanin (a huge polyphenolic biomacromolecule) in human, plants and animals. The irregularity in the expressions of this enzyme causes severe clinical problems in humann beings like hyperpigmentation and depigmentation, as well as vitiligo and albinism-type severe
dermatological problems. In addition, tyrosinase is known to be involved in the molting process of insect and adhesion of marine organisms. This enzyme and its receptors (TRP1 and TRP2) are involved in the skin melanoma. The gene and protein sequences of this enzyme and their primary, secondary, tertiary and quaternary structures have been analyzed through several bioinformatic approaches

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Published

2004-03-25

How to Cite

Khan, M. T. H. ., Atta-ur Rahman, & M. Iqbal Choudhary. (2004). In-Silico ANALYSIS OF THE GENE AND PROTEIN SEQUENCES OF THE ENZYME MUSHROOM TYROSINASE (POLYPHENOL OXIDASE, PPO). Pakistan Journal of Biotechnology, 1(1), 53–66. Retrieved from https://pjbt.org/index.php/pjbt/article/view/141

Issue

Vol. 1 No. 1 (2004): Pak. J. Biotechnology

Section

Research Articles